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Synthesis and metal-binding properties of chelating fluorescein derivatives
Matthew A Clark1, Kathryn Duffy, Jyoti Tibrewala
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Organic Letters
|June 7, 2003
Abstract:
[reaction: see text] Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC(50) values ranging from 0.4 to 60 microM. Compounds of this type may find application in biological sensing.