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Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of

Wei Jin1, Sammy Metobo, Robert M Williams

  • 1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

Organic Letters
|June 7, 2003
PubMed

Abstract:

[reaction: see text] The asymmetric synthesis of a highly functionalized pentacyclic tetrahydroisoquinoline relevant to the ecteinascidin, saframycin, safracin, and renieramycin family of antitumor alkaloids is described.

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