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Convenient synthesis of 2-benzazepines via radical cyclization
Akio Kamimura1, Yohei Taguchi, Yoji Omata
1Department of Applied Chemistry, Faculty of Engineering, Yamaguchi University, Ube 755-8611, Japan. ak10@yamaguchi-u.ac.jp
The Journal of Organic Chemistry
|June 7, 2003
Abstract:
Synthesis of 2-benzazepines was readily achieved via 7-endo radical cyclization of N-o-bromobenzylitaconamides or N-o-bromobenzylmethacrylamides which were prepared in two steps from commercially available benzaldehydes, amines, and alpha,beta-unsaturated acids.