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Synthesis of a novel cis-proline-derived cyclic type VI beta-turn mimic via ring-closing metathesis
Anima Boruah1, I Nageshwar Rao, Jyoti Prokash Nandy
1Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
The Journal of Organic Chemistry
|June 7, 2003
Abstract:
A cis-proline derived cyclic mimic of a type VI beta-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa beta-turn in CDCl(3) and a type VIb beta-turn in DMSO-d(6).