Related Experiment Video
Updated: Sep 25, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Mediastinitis complicating a percutaneous endoscopic gastrostomy: a case report
Kalliopi Papakonstantinou1, Athanasios Karagiannis, Maria Tsirantonaki
1Intensive Care Unit of Athens General Hospital, Athens, Greece. akarab@forthnet.gr
Background:
Since its introduction in the early 1980s, percutaneous endoscopic gastrostomy has become the most popular method for performing a gastrostomy for long-term enteral feeding. It has been associated, however, with a lot of minor and major complications.
Case Presentation:
A case of mediastinitis with concominant sepsis caused by a masked esophageal perforation after percutaneous endoscopic gastrostomy in a multi-traumatized, brain-injured patient is presented. Ten - fourteen days after the procedure, the patient became febrile and gradually septic with tenderness of the sternum and upper abdomen. Computerized tomography of the thorax revealed mediastinitis. An urgent left thoracotomy and laparotomy were performed for drainage of the mediastinum, removal of the gastrostomy and insertion of a jejunostomy tube. The patient improved soon after the surgery. He was successfully weaned off the ventilator and was discharged from the Intensive Care Unit.
Conclusion:
Perforating mediastinitis is a rare but potentially lethal complication of percutaneous endoscopic gastrostomy. When diagnosed and properly treated it may have a favourable outcome.
Insights
Percutaneous endoscopic gastrostomy (PEG) can lead to rare but serious complications like mediastinitis from esophageal perforation. Early diagnosis and surgical intervention are crucial for a favorable outcome in these critical cases.
Area of Science:
- Gastroenterology
- Surgical Endoscopy
- Critical Care Medicine
Background:
- Percutaneous endoscopic gastrostomy (PEG) is a widely adopted procedure for long-term enteral feeding.
- While generally safe, PEG is associated with various complications, ranging from minor to severe.
Observation:
- A case of masked esophageal perforation following PEG in a multi-traumatized patient is presented.
- The patient developed mediastinitis and sepsis 10-14 days post-procedure, indicated by fever, sternal tenderness, and CT findings.
- Surgical intervention included mediastinal drainage, gastrostomy removal, and jejunostomy placement.
Findings:
- Perforating mediastinitis is a rare but life-threatening complication of PEG.
- Prompt diagnosis and aggressive surgical management are essential for patient recovery.
- This case highlights the potential for favorable outcomes even with severe complications.
Implications:
- Clinicians should maintain a high index of suspicion for esophageal perforation in patients with delayed sepsis after PEG.
- Timely surgical intervention can prevent mortality associated with post-PEG mediastinitis.
- This case underscores the importance of comprehensive patient assessment and management in complex trauma scenarios involving PEG.
Related Concept Videos
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:
Endoscopic Procedures V: ERCP
Patient...
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus.