Treatment of skin malignancies

Malignant melanomas in situ can usually be treated in consultation with a specialist (C). Larger lesions may require referral. Based on best available evidence, surgical excision is the first-line treatment for most nonmelanoma skin cancers, with cure rates as high as 98% with proper margins. Consider Mohs surgery for larger lesions, sclerosing lesions with morpheaform histology, or for cosmetically sensitive areas. With properly selected lesions, curettage/electrodesiccation and cryosurgery have cure rates comparable to that of surgical excision.