Related Experiment Video

Updated: Aug 31, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Emergence of novel human group A rotavirus G12 strains in India

Soma Das1, V Varghese, S Chaudhury

  • 1Division of Virology, National Institute of Cholera and Enteric Diseases, Calcutta 700010, India.

Journal of Clinical Microbiology
|June 7, 2003
PubMed

Insights

Three rare G12 rotavirus strains were found in Indian infants with diarrhea. These strains show high genetic similarity to other global G12 strains, suggesting potential international spread of this rotavirus type.

Area of Science:

  • Virology
  • Pediatrics
  • Public Health

Background:

  • Rotaviral diarrhea is a significant cause of infant mortality globally.
  • Surveillance studies are crucial for monitoring the emergence and spread of rotavirus strains.
  • Human G12 rotavirus strains are considered rare and their epidemiology requires further investigation.

Purpose of the Study:

  • To detect and characterize rare human G12 rotavirus strains in India.
  • To compare the genetic makeup of detected G12 strains with other known G12 strains.
  • To understand the potential origins and spread of G12 rotavirus.

Main Methods:

  • Routine surveillance of diarrheic clinical samples from children in Calcutta, India.
  • Detection of rotavirus strains using molecular methods.
  • Sequence analysis of VP7 genes and their protein products.

Main Results:

  • Three rare human G12 rotavirus strains were identified in infants under 8 months of age.
  • The detected G12 strains exhibited high nucleotide (97-99%) and amino acid (98%) homology with G12 strains from the US and Thailand.
  • Lesser homology was observed with the prototype G12 strain L26.

Conclusions:

  • The findings indicate the circulation of rare G12 rotavirus strains in India.
  • The genetic similarity suggests a potential link or common origin with international G12 strains.
  • Further epidemiological studies are warranted to assess the prevalence and impact of G12 rotavirus in India and globally.

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions

Published on: September 10, 2021

Related Concept Videos

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...