Mutagenic effects of heavy charged particles

Heavy charged particles constitute the most important radiation risk in space. Since mutations can give rise to cancer the investigation of their induction may be helpful for risk quantification. This paper describes experiments in a number of mammalian cells performed with a large range of linear energy transfer (LET). RBE values are always found to increase with LET up to about 100 keV/microm and are similar to those suggested by ICRP. Molecular analyses demonstrate that heavy charged particles not only lead to sometimes very large deletions but also to smaller changes which might represent point mutations. Recent evidence shows that repair phenomena play an important role in the processing of initial DNA lesions to mutagenic alterations.