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Related Experiment Videos

Gene expression during oogenesis in mice.

P M Wassarman1, R A Kinloch

  • 1Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.

Mutation Research
|December 1, 1992
PubMed
Summary
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Program of early development in the mammal: synthesis and intracellular migration of histone H4 during oogenesis in the mouse.

Developmental biology·2010

Maternal stores in mouse eggs are built through gene expression, regulated at both the transcription and translation levels during oogenesis. This ensures successful fertilization and early embryo development.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Molecular Genetics

Background:

  • Oogenesis, the process of egg formation, begins during fetal development and concludes at fertilization.
  • Key events include germ cell formation, meiosis completion, and stockpiling maternal resources for early development.
  • Significant gene expression occurs during the growth phase in mature females, accumulating RNA and proteins.

Purpose of the Study:

  • To explore the transcriptional and translational regulation of maternal store establishment in growing mouse oocytes.
  • To present specific examples of gene expression regulation during mouse oogenesis.

Main Methods:

  • Analysis of gene expression patterns during mouse oocyte growth.
  • Investigating transcriptional control mechanisms.

Related Experiment Videos

  • Examining translational regulation of maternal factors.

    • Main Results:

    • Maternal store accumulation is confirmed to be regulated at both transcriptional and translational levels.
    • Specific instances of these regulatory mechanisms in mouse oogenesis are detailed.
    • High levels of ribonucleic acid and protein are characteristic of this developmental stage.

    Conclusions:

    • Gene expression during mouse oogenesis is tightly controlled transcriptionally and translationally.
    • These regulatory processes are crucial for establishing the maternal store vital for fertilization and preimplantation development.