Related Experiment Videos
Together at last: bHLH and LIM-HD regulators cooperate to specify motor neurons
1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Neuron
|June 12, 2003
Abstract:
bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between these factors functions to synchronize neurogenesis with neuronal cell type specification.