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Related Experiment Videos

c-jun regulation and function in the developing hindbrain.

Fatima Mechta-Grigoriou1, Francois Giudicelli, Cristina Pujades

  • 1Unité Expression génétique et maladies, CNRS URA 1644, Institut Pasteur 25, rue du Docteur Roux, 75724 15, Paris Cedex, France. fmechta@pasteur.fr

Developmental Biology
|June 12, 2003
PubMed
Summary
This summary is machine-generated.

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The protooncogene c-Jun works with MafB and Krox20 to regulate hindbrain segmentation by activating Hoxb3 gene expression. This reveals c-Jun

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Vertebrate hindbrain development involves precise segmentation.
  • The bZip transcription factor MafB/kreisler is crucial for caudal hindbrain segmentation, specifically in rhombomeres 5 and 6.
  • Understanding the genetic network controlling hindbrain patterning is essential.

Purpose of the Study:

  • To investigate the role of the protooncogene c-Jun in hindbrain segmentation.
  • To elucidate the relationship between c-Jun, MafB, and Krox20 in regulating gene expression in rhombomere 5.
  • To determine the molecular mechanisms by which c-Jun contributes to hindbrain patterning.

Main Methods:

  • Analysis of mouse mutants to study c-jun expression patterns.
  • Loss- and gain-of-function studies in mouse and chick embryos.

Related Experiment Videos

  • Investigation of transcription factor binding to regulatory elements of the Hoxb3 gene.

    • Main Results:

    • c-jun is coexpressed with MafB in prospective rhombomeres 5 and 6.
    • c-jun expression in these regions depends on MafB but not Krox20.
    • c-Jun, MafB, and Krox20 collaborate to transcriptionally activate the Hoxb3 gene in rhombomere 5.
    • c-Jun homodimers and c-Jun/MafB heterodimers bind to the Hoxb3 enhancer.

    Conclusions:

    • c-Jun acts as both a downstream effector and a cofactor of MafB in hindbrain development.
    • c-Jun is integrated into the complex regulatory network governing hindbrain segmentation.
    • These findings provide new insights into the genetic control of vertebrate hindbrain patterning.