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Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates

N G J Delaet1, L A Robinson, D M Wilson

  • 1CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA. ndelaet@kemia.com

Bioorganic & Medicinal Chemistry Letters
|June 12, 2003
PubMed

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Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...