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Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus
Kuo Long Yu1, Yi Zhang, Rita L Civiello
1Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5, Research Parkway, 06492, Wallingford, CT, USA.
Bioorganic & Medicinal Chemistry Letters
|June 12, 2003
Abstract:
Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.