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Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria
Jan Piwowarski1, Pawel Grzechnik, Andrzej Dziembowski
1Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5A, 02-106 Warsaw, Poland.
Journal of Molecular Biology
|June 12, 2003
Abstract:
The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.