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[Therapeutic indications of intravenous immunoglobulins]
1Laboratoire du fractionnement et des biotechnologies, direction des affaires médicales et de la recherche clinique, 3, avenue des Tropiques, BP 305, 91958 cedex, Les Ulis, France. tellier@lfb.fr <tellier@lfb.fr>
Intravenous Immunoglobulin (IVIg) provide a wide spectrum of antibody specificities in patients with antibody deficiencies and restore immune homeostasis in patients with auto-immune diseases. Controlled trials have now been performed in a large number of diseases: in primary and secondary antibody deficiencies, auto-immune neurological diseases and various other auto-immune or systemic inflammatory conditions. Mechanisms of action of IVIg are multiple and often associated for a given disease. These mechanisms are however incompletely understood and therapeutic effect of IVIg remains to be investigated in a wide range of diseases.
Intravenous Immunoglobulin (IVIg) provide a wide spectrum of antibody specificities in patients with antibody deficiencies and restore immune homeostasis in patients with auto-immune diseases. Controlled trials have now been performed in a large number of diseases: in primary and secondary antibody deficiencies, auto-immune neurological diseases and various other auto-immune or systemic inflammatory conditions. Mechanisms of action of IVIg are multiple and often associated for a given disease. These mechanisms are however incompletely understood and therapeutic effect of IVIg remains to be investigated in a wide range of diseases.