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Related Experiment Videos

Platelet surface glycoprotein expression in post-stroke depression: a preliminary study.

Eugene M Cassidy1, Marie-Therese Walsh, Rory O'Connor

  • 1Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland. eucass@hotmail.com

Psychiatry Research
|June 12, 2003
PubMed
Summary
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Depression and stroke patients show increased GPIb receptors on platelets compared to controls. This suggests platelet dysfunction may link depression and cerebrovascular disease.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Hematology

Background:

  • Depression is a known risk factor and consequence of cardiovascular disease and stroke.
  • The underlying pathophysiological mechanisms connecting depression and cerebrovascular disease remain unclear.

Purpose of the Study:

  • To investigate platelet surface glycoproteins involved in adhesion and aggregation in patients with depression and stroke.
  • To explore the role of platelet dysfunction in the association between depression and cerebrovascular disease.

Main Methods:

  • Flow cytometry was used to analyze platelet surface glycoproteins GPIb and GPIIbIIIa.
  • Sample populations included depressed subjects, post-stroke subjects (depressed and non-depressed), and healthy controls.

Related Experiment Videos

Main Results:

  • Subjects with depression and post-stroke subjects exhibited a significant increase in GPIb receptors compared to healthy controls.
  • No significant difference in GPIb receptors was found between post-stroke and depressed subjects.
  • No significant differences in GPIIbIIIa receptor numbers were observed across any groups.

Conclusions:

  • Increased GPIb receptors suggest potential platelet dysfunction in depression and post-stroke states.
  • Platelet dysfunction may play a role in the pathophysiology linking depression and cerebrovascular disease.
  • Comorbid depression did not show an additive effect on GPIb or GPIIbIIIa expression in post-stroke patients.