Related Experiment Videos
Interleukin-10 promoter polymorphisms in patients with Guillain-Barré syndrome
K-M Myhr1, K S Vågnes, T H Marøy
1Department of Neurology, Multiple Sclerosis National Competence Centre, Haukeland Hospital, University of Bergen, N-5021, Bergen, Norway. kjmy@haukeland.no
Journal of Neuroimmunology
|June 12, 2003
Abstract:
Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain-Barré syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (-1082 (G/A), -819 (T/C) and -592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The -592 CC and -819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls (P=0.027), but the polymorphisms did not influence the clinical course of the disease.