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Alpha 6 beta 1 Integrin is a potential clinical marker for evaluating sperm quality in men
Venkata Rami K Reddy1, Shrimali K Rajeev, Vijayalakshmi Gupta
1Immunology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, India. shrichi@rediffmail.com
Objective:
To determine the clinical significance of alpha6beta1 integrin in human spermatozoa.
Design:
Prospective case-controlled study.
Settings:
Hospital infertility clinic in India.
Patient(S):
Sixty-two men undergoing evaluation for infertility and 20 healthy, proven-fertile controls were selected.
Intervention(S):
Role of alpha6beta1integrin in sperm quality evaluation was determined using semen analysis, cell ELISA, flow cytometry, and in vitro sperm-egg binding.
Main Outcome Measure(S):
Determination of sperm-associated alpha6beta1 integrin may help in assessing the quality of the human spermatozoa.
Result(S):
Expression of alpha6beta1 integrin was significantly low in the spermatozoa obtained from subfertile men. Only 35%-40% of spermatozoa from fertile men showed a positive reaction to alpha6beta1 antibody. The samples with high rate of acrosomal reaction showed a good expression of alpha6beta1 and maximum binding to oocyte in an in vitro binding assay.
Conclusion(S):
alpha6beta1 Integrin may be used as a clinical marker to evaluate sperm quality.
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