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Updated: Sep 25, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Effects of oxytocin and prostaglandin F(2alpha) (enzaprost) on platelet aggregation
E K Ailamazyan1, N N Petrishchev, E V Vivulanets
1I. P. Pavlov St. Petersburg State Medical University.
Abstract:
The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8+/-25.7 nM).
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