Related Experiment Video

Updated: Sep 25, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
09:58

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Published on: June 5, 2012

Allergic dermatoses associated with chronic opisthorchiasis during antihelminthic therapy

L M Nepomnyashchikh1, S V Aidagulova, S R Senchukova

  • 1Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.ma.nsc.ru

Bulletin of Experimental Biology and Medicine
|June 13, 2003
PubMed

Insights

Opisthorchiasis, a parasitic infection, significantly contributes to allergic dermatoses by causing skin damage. Combination therapy, including antihelmintic drugs, effectively reverses these pathological changes.

Area of Science:

  • Dermatology
  • Parasitology
  • Pathology

Background:

  • Allergic dermatoses are common skin conditions.
  • Opisthorchiasis is a parasitic disease caused by liver flukes.
  • The link between opisthorchiasis and allergic skin conditions requires further investigation.

Purpose of the Study:

  • To investigate the role of opisthorchiasis in the pathogenesis of allergic dermatoses.
  • To analyze the structural changes in skin biopsy specimens from affected patients.
  • To evaluate the efficacy of combination therapy.

Main Methods:

  • Skin biopsy specimens were obtained from patients with allergic dermatoses and opisthorchiasis.
  • Histopathological examination was performed to assess structural changes in the epidermis and dermis.
  • The effects of combination therapy, including antihelmintic drugs, were evaluated.

Main Results:

  • Patients exhibited degenerative and destructive changes in epitheliocytes, hemodynamic disturbances, connective tissue disorganization, and progressive fibrosis.
  • Combination therapy led to regenerative processes in basal epidermal cells.
  • Therapy also stabilized the basal membrane and normalized the dermoepidermal junction.

Conclusions:

  • Opisthorchiasis plays a significant role in the pathogenesis of allergic dermatoses.
  • Combination therapy demonstrates a positive therapeutic effect on skin structure.
  • Regenerative processes and normalization of skin structures are key outcomes of the treatment.

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...