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Serum tumor necrosis factor-alpha in Guillain-Barré syndrome and its relation to plasma exchange
Sheela Reuben1, Annamma Mathai, Sumi M George
1Department of Pathology, Sree Chitra Tirunal Institute for Medical SciencesTechnology, Thiruvananthapuram-695 011, Kerala State, India.
Background:
To correlate the serum tumor necrosis factor-alpha (TNFalpha) concentrations before, during and following plasma exchange in patients with Guillain-Barré syndrome (GBS). In this prospective study, 21 GBS patients were selected. Patients in clinical stages III to V were subjected to plasma exchange. The control group included equal numbers of age-matched patients with other neurological diseases and healthy voluntary blood donors. A sandwich ELISA method was applied to estimate serum TNFalpha concentrations in test and control groups.
Review Summary:
Twelve GBS patients had elevated serum TNFalpha levels that ranged between 74 and 182 pg/mL. All 12 GBS patients showed a steady decrease in the TNFalpha concentration following plasma exchange and also showed a positive correlation with neurological recovery.
Conclusions:
We conclude that serum TNFalpha concentrations are elevated in 57.1% of GBS patients and TNFalpha level decreases following plasma exchange.
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