Related Experiment Videos
Generalized inflammation during peritonitis evidenced by intracutaneous E-selectin expression.
I Engelberts1, S C van Hoof, S K Samyo
1Department of Surgery, University of Limburg, Maastricht, The Netherlands.
Clinical Immunology and Immunopathology
|December 1, 1992
Summary
This study investigated E-selectin expression in skin during severe peritonitis. Results show significant E-selectin presence in patient skin, indicating widespread endothelial activation in inflammatory conditions.
Area of Science:
- Immunology
- Vascular Biology
- Gastroenterology
Background:
- E-selectin is an endothelial adhesion molecule involved in leukocyte adhesion.
- In vivo data on E-selectin expression, particularly during systemic inflammation, is limited.
Purpose of the Study:
- To investigate E-selectin expression in skin biopsies from patients with peritonitis.
- To determine if E-selectin expression in skin reflects a generalized inflammatory state.
Main Methods:
- Skin biopsies were collected from patients with gastrointestinal tract perforation and peritonitis.
- Immunohistochemical staining was performed to detect E-selectin expression.
- Biopsies from healthy individuals served as controls.
Main Results:
- Substantial E-selectin expression was detected on skin vasculature in 6 out of 8 severely ill patients.
- Skin from healthy individuals showed negative or faint patchy staining.
- E-selectin expression was observed at a distance from the primary inflammatory site.
Conclusions:
- E-selectin expression is induced in skin vasculature during severe peritonitis.
- Cutaneous E-selectin expression serves as a marker of generalized activated endothelium in systemic inflammation.