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Amylase-producing IgD-type multiple myeloma.

A Delannoy1, J Hamels, C Mecucci

  • 1Hôpital de Jolimont, La Louvière, Belgium.

Journal of Internal Medicine
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study reports a rare case of IgD-type multiple myeloma associated with hyperamylasemia, suggesting the malignant plasma cells secreted amylase. This finding expands the list of amylase-secreting tumors.

Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Hyperamylasemia can be caused by various conditions, including certain cancers.

Observation:

  • A 63-year-old woman presented with IgD-type multiple myeloma and elevated amylase levels.
  • Immunohistochemical and intracellular amylase analyses indicated secretion by malignant plasma cells.

Findings:

  • The malignant clone in this multiple myeloma case was responsible for amylase secretion.
  • Cytogenetic analysis revealed structural rearrangements on chromosome 1 near the amylase gene locus.

Implications:

  • Multiple myeloma should be recognized as a potential cause of hyperamylasemia.
  • This rare amylase-secreting tumor entity is not limited to Japan.

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