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Updated: Aug 17, 2026

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
Published on: September 17, 2012
Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase
Andrea Cavalli1, Marco De Vivo, Maurizio Recanatini
1University of Bologna, Department of Pharmaceutical Sciences, Via Belmeloro 6, I-40126 Bologna, Italy.
Abstract:
Density functional theory (DFT) calculations were carried out to study the molecular mechanism of the phosphoryl transfer reaction catalyzed by cyclin-dependent kinases (CDKs). The DFT study presented here shows that CDKs catalyze the phosphoryl transfer reaction from ATP to the serine substrate through a single step mechanism with a SN2-like transition state.
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