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CARD15/NOD2 analysis in rheumatoid arthritis susceptibility
I Ferreirós-Vidal1, F Barros, J L Pablos
1Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Objective:
To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA).
Methods:
The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls.
Results:
Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%).
Conclusion:
There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.