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Updated: Aug 20, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Antiepileptic drugs in the treatment of chronic headaches
E Agostoni1, R Frigerio, P Santoro
1Department of Neurology, University of Milan-Bicocca, San Gerardo Hospital, I-20052 Monza (MI), Italy.
Abstract:
In recent years, anticonvulsant drugs (AEDs) have been considered promising drugs in the prevention of migraine and other forms of headache, based on their action on the metabolism of gamma-aminobutyric acid (GABA) and glutamate. To date many AEDs are being evaluated for headache preventive treatment. The results are often encouraging even if not conclusive except for valproate, which has been extensively investigated and has been found to be effective and well tolerated in the preventive therapy of migraine. Other AEDs seem to be important in the treatment of patients with resistant headaches, with both migraine and epilepsy comorbid with mood and anxiety disorders or in neuropathic pain syndromes.
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