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Updated: Aug 8, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Thrombolysis in peripheral general practices in Scotland: another rule of halves
1Medicines Assessment Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZN.
Insights
General practitioners in Scotland increased thrombolysis adoption by 13% after facilitated visits, despite negative consultant attitudes. Improving access to pre-hospital thrombolysis is crucial for rural populations.
Area of Science:
- Cardiology
- Public Health
- General Practice
Background:
- Access to timely thrombolytic therapy is limited for rural populations in Scotland.
- Pre-hospital thrombolysis by general practitioners (GPs) offers a potential solution.
Purpose of the Study:
- To facilitate the adoption of thrombolytic therapy by GPs in peripheral Scottish practices.
- To assess the impact of consultant physician visits on thrombolysis policy adoption.
Main Methods:
- A survey of 182 peripheral practices (550,000 patients) assessed thrombolysis policies before and after consultant visits.
- Practices were located at least 30 minutes from a district general hospital.
- Hospital consultants' attitudes towards GP-administered thrombolysis were also surveyed.
Main Results:
- Thrombolysis policy adoption increased from 37% to 50% one year after facilitated visits.
- Most practices had electrocardiograph (87%) and defibrillator (76%) equipment.
- Negative consultant attitudes and inadequate health authority support were noted.
Conclusions:
- Pre-hospital thrombolysis by GPs is feasible, fast, safe, efficacious, and cost-effective for rural populations.
- Concerted professional effort and NHS management support are required for successful implementation.
- Addressing this public health issue requires improved access to timely thrombolytic therapy.
Objective:
To facilitate the adoption of thrombolysis by general practitioners in peripheral practices in Scotland.
Design:
Survey of practice policies on the management of acute myocardial infarction before and after practice visits by a consultant physician acting as a facilitator; survey of hospital consultants' attitudes to thrombolysis by general practitioners.
Setting:
One hundred and eighty-two practices, with an enlisted total of 550,000 patients, located at least 30 minutes from a district general hospital; 23 such hospitals serving these peripheral practices.
Main Outcome Measures:
Possession of electrocardiograph and defibrillator; adoption of a policy of giving thrombolytic therapy.
Results:
The majority of practices possessed an electrocardiograph (87%) and a defibrillator (76%). At the time of the visits, 67 practices (37%) already had a policy of giving thrombolytic therapy. When contacted one year later 91 practices (50%) had such a policy. In the interval between visits and follow-up, few had received any encouragement from any source to use this treatment. Hospital consultants' attitudes to thrombolysis by general practitioners were generally negative, and support from local and national health authorities has been inadequate.
Conclusions:
Provision of timely thrombolytic therapy for the one tenth of the Scottish population living at least 30 minutes from a district general hospital is a major public health problem for which there is a ready solution: pre-hospital thrombolysis administered by general practitioners has been shown to be feasible, fast, safe, efficacious and cost-effective. To translate this evidence into practice requires a concerted effort from all the professionals involved, and must be directed and supported by local and national management of the National Health Service in Scotland.
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