Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Mitomycin-induced hemolytic-uremic syndrome].

G Zeller¹, E Wandel, A Schwarting

¹I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz.

Deutsche Medizinische Wochenschrift (1946)

|June 19, 2003

Summary

Mitomycin C chemotherapy can cause severe kidney damage, leading to hemolytic uremic syndrome. Prompt diagnosis and treatment with plasma separation and corticosteroids are crucial for recovery, especially when lung involvement occurs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Following the long-term evolution of sp<sup>3</sup>-type defects in tritiated graphene using Raman spectroscopy.

Nanoscale advances·2026

Same author

[Management of systemic lupus erythematosus-Including secondary antiphospholipid syndrome, fertility and pregnancy : S3 guidelines of the German Society for Rheumatology and Clinical Immunology and the German Society for Neurology (DGN), German Society for Internal Medicine (DGIM), German Cardiac Society (DGK), Society for Thrombosis and Hemostasis Research (GTH), German Society for Hematology and Medical Oncology (DGHO), German Society for Pediatric and Adolescent Medicine (DGKJ), Society for Pediatric and Adolescent Rheumatology (GKJR), German Society for Nephrology (DGfN), German Society for Pneumology and Ventilation Medicine (DGP), German Rheumatism League National Association, Lupus Erythematosus Self-help Community, German Dermatological Society (DDG). Version: 1.2].

Zeitschrift fur Rheumatologie·2025

Same author

First Constraints on General Neutrino Interactions Based on KATRIN Data.

Physical review letters·2025

Same author

[Update on lupus nephritis].

Zeitschrift fur Rheumatologie·2024

Same author

[The subanalysis of Rheuma-VOR demonstrates a considerable need for rheumatological care].

Zeitschrift fur Rheumatologie·2024

Same author

New Constraint on the Local Relic Neutrino Background Overdensity with the First KATRIN Data Runs.

Physical review letters·2022

Area of Science:

Nephrology
Oncology
Hematology

Background:

A 58-year-old patient developed rapidly progressive renal insufficiency and significant weight loss three months post-adjuvant chemotherapy for lower bowel carcinoma.
The patient presented with anuria, pulmonary edema, hemolytic anemia, and thrombocytopenia upon hospitalization.

Observation:

A 58-year-old patient developed rapidly progressive renal insufficiency, hemolytic anemia, thrombocytopenia, and pulmonary edema three months post-mitomycin C treatment.
Renal biopsy showed mesangiolysis and onion-skinning, indicative of thrombotic microangiopathy. Bone marrow examination revealed toxic damage.

Findings:

The patient presented with anuria, pulmonary hemorrhage, hemolytic anemia, and thrombocytopenia, consistent with severe HUS.
Computed tomography and bronchial endoscopy confirmed pulmonary hemorrhage, while renal biopsy revealed characteristic changes of HUS.

Related Experiment Videos

Implications:

Pulmonary involvement in HUS is rare and associated with high mortality, necessitating prompt and accurate diagnosis.
Plasma separation and high-dose corticosteroid therapy led to recovery, highlighting their efficacy in managing severe HUS.
Dose adaptation of mitomycin C is essential in patients with renal impairment to prevent dose-dependent toxicity and avoid HUS.