Related Experiment Videos
Calretinin expression in odontogenic cysts.
Adriano Piattelli1, Massimiliano Fioroni, Giovanna Iezzi
1Dental School, University of Chieti, Italy.
Journal of Endodontics
|June 20, 2003
Summary
Calretinin is not found in most common jaw cysts, but it is present in the epithelium of parakeratinized keratocysts. This finding may explain differences in the behavior of these odontogenic cysts.
Area of Science:
- Oral pathology
- Biochemistry
- Cell biology
Background:
- Calretinin, a calcium-binding protein, is found in neural tissue and is a marker for mesothelial cells.
- It is expressed in odontogenic epithelium and ameloblastomas, but not in odontogenic keratocysts or other common cysts.
- Its role in cell cycle regulation suggests potential involvement in cyst behavior.
Purpose of the Study:
- To investigate calretinin expression in various odontogenic cysts.
- To compare calretinin presence in radicular cysts, follicular cysts, orthokeratinized keratocysts, and parakeratinized keratocysts.
Main Methods:
- Immunohistochemical evaluation of calretinin expression.
- Analysis of 70 odontogenic cysts: 24 radicular, 24 follicular, and 22 odontogenic keratocysts (10 orthokeratinized, 12 parakeratinized).
Main Results:
- Radicular cysts, follicular cysts, and orthokeratinized keratocysts showed no calretinin staining.
- Calretinin was detected in the parabasal-intermediate layers of the epithelium in 8 out of 12 parakeratinized keratocysts.
Conclusions:
- Calretinin expression is absent in radicular, follicular, and orthokeratinized keratocysts.
- Positivity in parakeratinized keratocysts suggests potential cell cycle dysregulation, differentiating them from orthokeratinized types.
- Calretinin may serve as a marker to distinguish between different types of odontogenic keratocysts.