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Normal intracortical excitability in developmental stuttering.

Martin Sommer1, Stephan Wischer, Frithjof Tergau

  • 1Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany. msommer@gwdg.de

Movement Disorders : Official Journal of the Movement Disorder Society
|June 20, 2003
PubMed
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Persistent developmental stuttering (PDS) shows normal intracortical excitability, unlike task-specific dystonias. Increased motor thresholds in PDS suggest reduced cortical neuronal membrane excitability, not weakened inhibition.

Area of Science:

  • Neuroscience
  • Speech-Language Pathology

Background:

  • Persistent developmental stuttering (PDS) exhibits clinical similarities to task-specific dystonias.
  • Task-specific dystonias are characterized by abnormally weak intracortical inhibition.

Purpose of the Study:

  • To investigate intracortical inhibition and facilitation in individuals with PDS.
  • To compare cortical excitability in PDS with speech-fluent controls.

Main Methods:

  • Transcranial magnetic stimulation (TMS) was used to assess motor cortical excitability.
  • Resting and active motor thresholds, intracortical inhibition, and facilitation were measured in the abductor digiti minimi muscle representation.
  • 18 subjects with PDS and 18 controls participated.

Main Results:

Related Experiment Videos

  • Individuals with PDS had increased resting and active motor thresholds compared to controls.
  • Intracortical inhibition and facilitation were found to be normal in PDS.
  • These findings suggest reduced motor cortical neuronal membrane excitability in PDS.

Conclusions:

  • Normal intracortical excitability in PDS makes a direct pathophysiological analogy with focal dystonia less likely.
  • The elevated motor threshold in PDS indicates altered cortical excitability, potentially related to membrane properties rather than inhibitory circuits.