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Synthesis and antiherpetic activity of acyclovir phosphonates
Inna L Karpenko1, Maxim V Jasko, Valeriya L Andronova
1Engelhardt Institute of Molecular Biology, Russian Academy of Medical Sciences, Moscow, Russian Federation.
Nucleosides, Nucleotides & Nucleic Acids
|June 21, 2003
Abstract:
Phosphonate derivatives of acyclovir containing phosphorous acid and ethoxycarbonylphosphonic acid residues as well as their isopropyl esters were prepared. They selectively inhibited the herpes simplex virus 1 reproduction in Vero cell culture, the efficacy of esters being 3-4 times higher than that of ACV. The hydrolysis of the synthesized compounds was studied in the PBS buffer and human blood serum.