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[Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma]
Chao-chun Zou1, Lan-fang Tang, Mi-zu Jiang
1The Children's Hospital of Zhejiang University School of Medicine, Hangzhoua 310003, China.
Objective:
To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma.
Method:
Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method.
Results:
The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47).
Conclusion:
These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.