[Research progress of metabolomics in the pathogenesis and treatment of constipation in children]

Area of Science:

• Pediatric functional gastrointestinal disorders
• Systems biology applications in medicine
• Metabolomics and disease research

Background:

• Pediatric constipation is a prevalent functional gastrointestinal disorder impacting children's quality of life.
• Traditional research methods face challenges in fully understanding constipation's complex causes and individual differences.
• Metabolomics offers a powerful tool for systematic analysis of metabolites in disease research.

Purpose of the Study:

• To review the application of metabolomics in pediatric constipation research.
• To summarize characteristic metabolite profile changes and regulatory mechanisms in pediatric constipation.
• To evaluate potential pathogenic mechanisms and therapeutic targets for individualized treatment.

Main Methods:

• Systematic review of metabolomics studies in pediatric constipation.
• Analysis of metabolite profiles and metabolic pathway regulation.
• Evaluation of pathogenic mechanisms and therapeutic targets based on metabolomic data.

Main Results:

• Metabolomics identifies specific metabolite alterations in children with constipation.
• Changes in metabolic pathways provide insights into the pathophysiology of pediatric constipation.
• This approach highlights potential targets for novel therapeutic strategies.

Conclusions:

• Metabolomics provides a comprehensive understanding of pediatric constipation's etiology.
• Metabolomic findings can guide the development of individualized treatment plans.
• Future research directions include further validation and clinical application of metabolomic discoveries.