[Study on the clinical use of alpha-fetoprotein (AFP) colloidal gold diagnostic strip]

¹Beijing Institute of Biological Prodects, Beijing 100024, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi

|June 21, 2003

Abstract

Objective:

To test the sensitivity and specificity of alpha-fetoprotein (AFP) colloidal gold diagnostic strip as compared with RIA-AFP diagnostic kit.

Methods:

Double blind method was used to test sera from 426 healthy people and 1567 patients selected in two general hospitals and a cancer hospital. Each serum was measured by RIA-AFP and AFP colloidal gold diagnostic strip on the same day. RIA-AFP diagnostic results was identified as true positive or negative.

Results:

Among 426 healthy people, all the RIA-AFP test showed negative result (serum AFP concentration less than 25 IU/ml), but the AFP colloidal gold diagnostic strip had 1.88% false positive. When comparing the result from 1567 patients measured by RIA-AFP, the sensitivity and specificity of AFP colloidal gold diagnostic strip were 99.3%, and 97.2%, respectively. The crude correspondence rate between the two diagnostic regents was 97.6%.

Conclusion:

AFP colloidal gold diagnostic strip showed very good result and could be used as a screening diagnostic kit in clinic and hospital settings.

Keywords:

alpha-fetoprotein testing colloidal gold diagnostic clinical diagnostic comparison point-of-care AFP testing

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[Study on the clinical use of alpha-fetoprotein (AFP) colloidal gold diagnostic strip]

Objective:

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Results:

Conclusion:

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