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Aging of microstructural compartments in human compact bone.

Ozan Akkus1, Anna Polyakova-Akkus, Fran Adar

  • 1Department of Bioengineering, University of Toledo, Toledo, Ohio 43606-3390, USA. ozan.akkus@utoledo.edu

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|June 24, 2003
PubMed
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Bone aging involves continuous mineralization over two decades. Slowing bone remodeling may increase fracture risk due to accumulation of highly mineralized tissue.

Area of Science:

  • Biomaterials Science
  • Skeletal Biology
  • Gerontology

Background:

  • Bone tissue composition changes with age.
  • Bone remodeling's role in maintaining tissue quality is crucial.
  • Understanding microstructural aging is key to bone health.

Purpose of the Study:

  • Investigate the aging process in human femoral cortical bone microstructural compartments.
  • Relate aging to changes in overall bone tissue composition.
  • Assess the impact of mineralization and remodeling on bone fragility.

Main Methods:

  • Raman microscopy and microprobe analysis were used.
  • Assessed mineral content, crystallinity, and carbonate substitution in bone.
  • Analyzed both unremodeled primary bone and secondary osteons.
Keywords:
NASA Discipline MusculoskeletalNASA Program Biomedical Research and CountermeasuresNon-NASA Center

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Main Results:

  • Primary bone mineralization and crystal maturation occurred over two decades.
  • Secondary osteonal remodeling maintained constant mean bone composition.
  • Unremodeled bone accumulated highly mineralized tissue with age.

Conclusions:

  • Bone mineralization is a protracted process.
  • Bone remodeling prevents accumulation of fully mineralized, potentially brittle tissue.
  • Reduced bone remodeling may increase fracture susceptibility.