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Updated: Aug 16, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Effect of recombinant human growth hormone treatment on glucose metabolism]
1II Klinika Chorób Dzieci Instytutu Pediatrii AM w Łodzi. Łodz.
Abstract:
Deciding to administer human growth hormone (hGH, somatotrophin) physicians often consider the possibility of adverse reactions of such a treatment, and among the others, they have regard to its effects on glucose metabolism. The problem is particularly important in patients treated with higher than physiological doses of hGH (children with constitutional short stature, girls with Turner's syndrome). Recent studies suggest, that although the effect of hGH on glucose metabolism is undeniable, replacement doses of this hormone practically do not threaten with diabetes development, but its higher than physiological doses can impair insulin secretion and, in exceptional cases, cause transient diabetes.
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