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Related Experiment Videos

Ventricular function abnormalities in active rheumatoid arthritis: a Doppler echocardiographic study.

Funda Levendoglu1, Ahmet Temizhan, Hatice Ugurlu

  • 1Department of Physical Medicine and Rehabilitation, Meram Medical School of Selcuk University, Meram-Konya, Turkey. Levendogluf@hotmail.com

Rheumatology International
|June 24, 2003
PubMed
Summary

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Active rheumatoid arthritis (RA) patients show impaired diastolic function in both heart ventricles. This subclinical myocardial involvement correlates with disease duration, suggesting early cardiac changes in RA.

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory disease.
  • Cardiac involvement is a significant concern in RA patients.
  • Subclinical myocardial dysfunction may precede overt cardiovascular events.

Purpose of the Study:

  • To assess cardiac involvement in patients with active rheumatoid arthritis (RA).
  • To evaluate diastolic function in both ventricles of RA patients.
  • To investigate the relationship between cardiac parameters and disease duration in RA.

Main Methods:

  • Study included 40 patients with active RA.
  • Standard Doppler echocardiography was performed on all participants.
  • Myocardial Performance Index (MPI) grading was utilized to assess cardiac function.

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Main Results:

  • Abnormalities in left and right ventricular diastolic function were observed in RA patients.
  • Left ventricular MPI was significantly elevated compared to controls (P<0.05).
  • A correlation was found between left ventricular diastolic function parameters (E/A ratio, IRT) and RA disease duration.

Conclusions:

  • Diastolic dysfunction is prevalent in both ventricles of active RA patients.
  • Cardiac diastolic function parameters are linked to disease duration in RA.
  • Findings indicate subclinical myocardial impairment in RA, warranting further investigation.