Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Floating dosage systems in drug delivery.

L Hari Vardhan Reddy1, R S R Murthy

  • 1Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, M.S. University of Baroda, Vadodara-390001, Gujarat, India.

Critical Reviews in Therapeutic Drug Carrier Systems
|June 26, 2003
PubMed
Summary

New therapeutic molecules with poor gastrointestinal absorption or requiring localized stomach action benefit from specialized floating dosage systems (FDS). These systems enhance drug delivery to absorption windows and treat gastric disorders effectively.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Fusion and binding inhibition" key target for HIV-1 treatment and pre-exposure prophylaxis: targets, drug delivery and nanotechnology approaches.

Drug delivery·2017
Same author

Effect of Different Polymer Concentration on Drug Release Rate and Physicochemical Properties of Mucoadhesive Gastroretentive Tablets.

Indian journal of pharmaceutical sciences·2016
Same author

Spray-dried particles as pulmonary delivery system of anti-tubercular drugs: design, optimization, in vitro and in vivo evaluation.

Pharmaceutical development and technology·2015
Same author

EILDV-conjugated, etoposide-loaded biodegradable polymeric micelles directing to tumor metastatic cells overexpressing α4β1 integrin.

Cancer nanotechnology·2015
Same author

PLGA nanoparticles loaded with etoposide and quercetin dihydrate individually: in vitro cell line study to ensure advantage of combination therapy.

Cancer nanotechnology·2015
Same author

Gemcitabine-loaded PLGA-PEG immunonanoparticles for targeted chemotherapy of pancreatic cancer.

Cancer nanotechnology·2015

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Emerging diseases and drug resistance necessitate novel therapeutic molecules.
  • Many new chemical entities exhibit limited gastrointestinal absorption, solubility, or require localized gastric action.

Purpose of the Study:

  • To review the development and application of floating dosage systems (FDS) for enhanced drug delivery.
  • To discuss factors influencing gastric retention and various FDS technologies.

Main Methods:

  • Review of existing literature on gastrointestinal physiology and drug absorption.
  • Analysis of different floating dosage system technologies (HBS, gas-generating, microspheres, rafts).
  • Discussion of factors affecting gastric emptying and retention.

Main Results:

Related Experiment Videos

  • Floating dosage systems (FDS) offer a solution for drugs with specific absorption profiles or requiring gastric action.
  • Various FDS technologies exist, each with unique advantages and limitations.
  • Gastrointestinal physiology, dosage form design, and patient factors critically influence FDS performance.

Conclusions:

  • FDS are crucial for optimizing the delivery of challenging drug molecules.
  • Understanding gastric physiology is key to designing effective FDS.
  • Continued innovation in FDS technology is vital for pharmaceutical development.