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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates
L A Robinson1, D M Wilson, N G J Delaet
1CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA.
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.

