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Updated: Jun 9, 2026
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A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
PROTINFO: Secondary and tertiary protein structure prediction.
Ling-Hong Hung1, Ram Samudrala
1Computational Genomics Group, Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Nucleic Acids Research
|June 26, 2003
Summary
The PROTINFO server predicts protein structures using advanced methods and assigns secondary structures from NMR data. This aids biologists in hypothesis generation and experimental design for protein research.
Area of Science:
- Biochemistry
- Structural Biology
- Bioinformatics
Background:
- Understanding protein secondary and tertiary structures is crucial for biological research.
- Accurate structure prediction and assignment facilitate hypothesis generation and experimental design.
Purpose of the Study:
- To introduce the PROTINFO server for protein structure prediction and secondary structure assignment.
- To provide biologists with a tool for analyzing protein sequences and NMR data.
Main Methods:
- Tertiary structure prediction via comparative modeling, fold generation, and de novo methods.
- Secondary structure assignment using neural networks trained on NMR chemical shift data and secondary structure predictions.
Main Results:
- The PROTINFO server offers predictions of three-dimensional protein structures.
- The server provides secondary structure assignment based on user-submitted NMR chemical shift data.
Conclusions:
- The PROTINFO server is a valuable resource for protein structure analysis.
- This tool supports biological hypothesis testing and experimental design through accurate structural information.
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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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