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Tcoffee@igs: A web server for computing, evaluating and combining multiple sequence alignments.

Olivier Poirot1, Eamonn O'Toole, Cedric Notredame

  • 1Information Genomique et Structurale, CNRS, 31 Chemin Joseph Aiguier, 13 402 Marseille Cedex 20, France.

Nucleic Acids Research
|June 26, 2003
PubMed
Summary
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The Tcoffee@igs server offers a web-based tool for computing, evaluating, and combining multiple sequence alignments. This bioinformatics resource aids in analyzing protein, RNA, and DNA sequences, generating alignments and phylogenetic trees.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Multiple sequence alignment (MSA) is crucial for understanding protein and nucleic acid evolution and function.
  • Existing tools may lack integrated evaluation and combination capabilities for MSAs.

Purpose of the Study:

  • To introduce Tcoffee@igs, a novel web server for advanced multiple sequence alignment analysis.
  • To provide a user-friendly platform for computing, evaluating, and merging sequence alignments.

Main Methods:

  • Utilizes the latest T-Coffee package for sequence alignment computation.
  • Web-based interface for uploading unaligned sequences or existing alignments.
  • Incorporates algorithms for alignment evaluation and combination.

Related Experiment Videos

Main Results:

  • Generates evaluated multiple sequence alignments and associated phylogenetic trees.
  • Enables assessment of local alignment reliability.
  • Facilitates the combination of multiple alternative alignments into a single consensus alignment.
  • Supports protein, RNA, and DNA sequence data.

Conclusions:

  • Tcoffee@igs provides a comprehensive solution for multiple sequence alignment challenges.
  • The server enhances the reliability and utility of sequence alignments for biological research.
  • Accessible tool for researchers in molecular biology, genomics, and evolutionary studies.