Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

When the darker eye has the smaller pupil.

David H Wallis1, David B Granet, Leah Levi

  • 1The Santa Monica UCLA Family Practice Residency Program, University of California, San Diego, La Jolla, CA, USA.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|June 26, 2003
PubMed
Summary

Congenital Horner syndrome and Waardenburg syndrome can cause iris color changes. This case highlights a rare presentation where Waardenburg syndrome altered the typical iris appearance in congenital Horner syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bupivacaine-Induced Regeneration in Rabbit Extraocular Muscles: Implications for the Treatment of Strabismus.

Ophthalmology science·2026
Same author

Applications of Generative Artificial Intelligence for Strabismus Surgery Video-Based Education.

Ophthalmology science·2026
Same author

But doctor, will I be able to drive? Car mirror placement design and viewing angles required for safe binocular vision for drivers.

The British journal of ophthalmology·2025
Same author

Epidemiology of strabismus among adults in the United States: insights from the All of Us database.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2025
Same author

Socioeconomic trends of adult strabismus in the United States: an analysis of the All of Us database.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2025
Same author

Iris color distribution in the United States of America.

PloS one·2025

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Waardenburg syndrome and congenital Horner syndrome are known causes of congenital hypochromic iris heterochromia.
  • Both conditions are associated with impaired tyrosinase induction, leading to reduced iris melanin production.

Observation:

  • A rare case of a 20-month-old boy presenting with both congenital Horner syndrome and Waardenburg syndrome (type II) is described.
  • Unusually, the iris affected by congenital Horner syndrome was darker due to the concurrent Waardenburg syndrome's impact on the contralateral iris.

Findings:

  • This case presents a unique interaction between Waardenburg syndrome and congenital Horner syndrome.
  • The darker iris in congenital Horner syndrome is an atypical finding, attributed to the combined effects of both syndromes.

Related Experiment Videos

Implications:

  • This case underscores the importance of considering both Waardenburg and congenital Horner syndromes in the differential diagnosis of heterochromia iridis.
  • It offers insights into the complex pathophysiology of iris pigmentation disorders and their combined presentation.