Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans.

Pekka Talke1, Errol Lobo, Ronald Brown

  • 1Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, 94143, USA. talkep@anesthesia.ucsf.edu

Anesthesiology
|June 27, 2003
PubMed
Summary

Dexmedetomidine causes vasoconstriction by activating alpha(2)-adrenoceptors. This study isolated vasoconstrictive effects by reducing sympatholytic activity, revealing dose-dependent vasoconstriction in sympathectomized hands.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vasomotion in Human Fingers.

Journal of vascular research·2025
Same author

Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank.

Nucleic acids research·2024
Same author

Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study.

Journal of pain research·2024
Same author

Oral Nodular Chronic Hyperplastic Candidiasis of the Tongue: A Case Report.

Cureus·2023
Same author

Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial.

Reviews on recent clinical trials·2023
Same author

Impact of the coronavirus disease 2019 pandemic on an academic vascular practice and a multidisciplinary limb preservation program.

Journal of vascular surgery·2020

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology

Background:

  • Alpha(2)-adrenoceptors influence both sympatholytic and vasoconstrictive effects.
  • Selective alpha(2)-adrenoceptor agonists can have dual hemodynamic actions.

Purpose of the Study:

  • To isolate and characterize the peripheral vasoconstrictive effects of dexmedetomidine.
  • To understand vasoconstriction independent of sympatholytic actions.

Main Methods:

  • Administered increasing concentrations of dexmedetomidine or placebo to volunteers.
  • Attenuated sympatholytic effects via general anesthesia or brachial plexus block.
  • Measured finger blood volume (vasoconstriction) and hemodynamics.

Main Results:

  • Anesthetized volunteers showed vasoconstriction (increased LTF) with dexmedetomidine.

Related Experiment Videos

  • Awake volunteers exhibited vasodilation (decreased LTF) in neurally intact hands.
  • Dexmedetomidine induced dose-dependent vasoconstriction in sympathectomized hands.

    • Conclusions:

    • First characterization of the lower dose-response curve for dexmedetomidine-induced vasoconstriction.
    • Sympathetic nervous system activity significantly modulates alpha(2)-agonist vasoconstrictive effects.
    • Dexmedetomidine's vasoconstrictive potential can be observed by minimizing sympatholysis.