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[New concepts in hyperactive malarial splenomegaly]
M F Moraes1, M Soares, M J Arroz
1Serviço de Medicina II, Hospital de Egas Moniz, Instituto de Higiene e Medicina Tropical, Lisboa.
Acta Medica Portuguesa
|June 28, 2003
Abstract:
Hyperreactive malarial splenomegaly is thought to represent an immunological dysfunction due to recurrent episodes of malaria. The authors present a case of hyperreactive malarial splenomegaly in a patient from São Tomé e Príncipe and discuss aspects of its differential diagnosis and treatment. A revision is made of recent concepts related to its pathogenesis and relationship with lymphoproliferative disorders. Malarial DNA was found in the absence of parasite forms in the peripheral blood. This may indicate that latent infection plays a role in its pathogenesis.