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Updated: Sep 12, 2026

Genome Editing in the Yellow Fever Mosquito Aedes aegypti using CRISPR-Cas9
Published on: March 21, 2025
Identification of an unannotated early embryonic single-minded transcript in the yellow fever mosquito Aedes aegypti
1Department of Biochemistry, University at Buffalo-State University of New York, Buffalo, New York, United States.
Abstract:
The yellow fever mosquito, Aedes aegypti , is a cosmopolitan species that serves as the vector of multiple disease causing agents including dengue, chikungunya, Zika, and yellow fever viruses. The genome of Ae. aegypti has been characterized at the chromosome level, but further manual refinement is required for genes and isoforms with transient expression or low abundance. Here we report on the identification of an early embryonic transcript for the single-minded (sim ) gene in Ae. aegypti , and present the putative promoter for the transcript. The identification of an early-driven transcript is consistent with the annotation for sim in Drosophila melanogaster.

