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Polymicrogyria in monozygous twins and an elder sibling.
Po-Cheng Hung1, Huei-Shyong Wang
1Division of Pediatric Neurology, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. hongfh@ms14.hinet.net
Developmental Medicine and Child Neurology
|June 28, 2003
Summary
Monozygotic twins often experience brain lesions, but polymicrogyria is rare. This study suggests a genetic cause for polymicrogyria in twins, alongside circulatory issues.
Area of Science:
- Neuroscience
- Genetics
- Developmental Biology
Background:
- Monozygotic twins are predisposed to specific brain lesions like hydranencephaly, multicystic encephalomalacia, and porencephaly.
- Prenatal circulatory injury is the commonly accepted cause for these observed brain abnormalities.
Observation:
- A case involving monozygotic male twins and their elder sister presented with global developmental delay.
- Brain Magnetic Resonance Imaging (MRI) revealed polymicrogyria in all affected siblings.
Findings:
- Polymicrogyria, a rare cortical malformation, was diagnosed in the monozygotic twins and their sibling.
- The co-occurrence of polymicrogyria and global developmental delay within the sibship suggests a potential underlying etiology.
Implications:
- This case highlights the need to consider genetic factors in the etiology of polymicrogyria, particularly in the context of monozygotic twins.
- Further research into genetic contributions could improve understanding and diagnosis of polymicrogyria and associated developmental delays.