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Relationship between coagulation cascade, cytokine, adhesion molecule and aortic aneurysm
Fumikazu Nomura1, Akihiro Ihara, Masao Yoshitatsu
1Department of Cardiovascular Surgery, National Hospital Kure Medical Center, 3-1 Aoyama, Kure, 737-0023, Hiroshima, Japan. fnomura@kure-nh.go.jp
Summary
Aortic aneurysm patients exhibit hypercoagulation and inflammation. Biomarkers like TAT, D-dimer, and sIL-2R correlate with aneurysm size, aiding disease monitoring.
Area of Science:
- Vascular Biology
- Coagulation Science
- Inflammatory Diseases
Background:
- Aortic aneurysm (AA) is linked to chronic inflammation and disseminated intravascular coagulation.
- Atherosclerosis, a related inflammatory condition, involves immune cells and cytokines.
- Understanding coagulation status and inflammatory markers in AA is crucial for disease management.
Purpose of the Study:
- To investigate coagulation status, cytokine levels, adhesion molecules, and collagen turnover in AA patients.
- To determine the relationship between these markers and aortic aneurysm size.
Main Methods:
- Measured thrombin-antithrombin III complex (TAT), D-dimer, type III procollagen peptide (PIIIP), soluble IL-2 receptor (sIL-2R), tissue factor pathway inhibitor (TFPI), and soluble ICAM-1 in 17 AA patients.
- Utilized computed tomography (CT) for aneurysm size and volume measurements.
- Compared AA patients with age-matched healthy volunteers.
Main Results:
- AA patients showed significantly elevated TAT, D-dimer, sIL-2R, and TFPI compared to controls.
- No significant difference was observed in PIIIP or ICAM-1 levels between groups.
- TAT, D-dimer, sIL-2R, PIIIP, and sICAM-1 positively correlated with aortic aneurysm size.
- TAT, D-dimer, and sIL-2R also correlated with aneurysmal volume.
Conclusions:
- Patients with aortic aneurysms are in a state of hypercoagulation and inflammation.
- Markers such as TAT, D-dimer, sIL-2R, PIIIP, and sICAM-1 are valuable for diagnosing and monitoring AA progression.