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Related Experiment Videos

Microbial ferric iron reductases.

Imke Schröder1, Eric Johnson, Simon de Vries

  • 1Department of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, 1602 Molecular Sciences Bldg., Los Angeles, CA 90095-1489, USA. imkes@microbio.ucla.edu

FEMS Microbiology Reviews
|June 28, 2003
PubMed
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Iron is essential for life. This review covers ferric reductases, enzymes crucial for iron uptake in bacteria, archaea, and yeast, highlighting their distinct roles and evolutionary strategies.

Area of Science:

  • Biochemistry
  • Microbiology
  • Molecular Biology

Background:

  • Iron is vital for cellular enzymes across all organisms.
  • Aerobic microbes face challenges with iron availability due to ferric iron insolubility at neutral/alkaline pH.
  • Ferric reductases are key enzymes for iron assimilation and respiration.

Purpose of the Study:

  • To review the physiological function and structure of assimilatory and dissimilatory ferric reductases.
  • To explore the distinct roles of these enzymes in Bacteria, Archaea, and Yeast.
  • To understand the evolutionary strategies of iron reduction.

Main Methods:

  • Literature review of research over the last 10 years.
  • Analysis of the roles of flavin reductases in bacterial iron assimilation.

Related Experiment Videos

  • Comparison of assimilatory and dissimilatory ferric reductases.

    • Main Results:

    • Most bacterial assimilatory ferric reductases are flavin reductases with diverse physiological roles.
    • Dissimilatory ferric reductases are distinct from assimilatory types and are crucial for iron respiration.
    • Ferric reductases represent distinct enzyme families, indicating convergent evolution.

    Conclusions:

    • Ferric reductases are essential for iron metabolism in diverse organisms.
    • Distinct evolutionary pathways have led to diverse ferric reductase enzymes.
    • Further research is needed to fully understand dissimilatory ferric reductases.