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Ceftriaxone-associated nephrolithiasis and biliary pseudolithiasis in a child
Jeffrey S Prince1, Melvin O Senac
1Department of Radiology, UCSD Medical Center, 200 West Arbor Dr., Mail Code 8756, San Diego, CA 92103-8756, USA. jeffreysprince@earthlink.net
Pediatric Radiology
|June 28, 2003
Summary
Ceftriaxone, a common antibiotic, can rarely cause gallstones and kidney stones in children. These side effects usually resolve after stopping the medication but can mimic serious conditions.
Area of Science:
- Pediatric Nephrology
- Pediatric Gastroenterology
- Clinical Pharmacology
Background:
- Ceftriaxone is a third-generation cephalosporin antibiotic frequently used in pediatric care.
- While generally safe, rare adverse events like biliary pseudolithiasis and nephrolithiasis have been documented.
- Understanding these potential complications is crucial for accurate diagnosis and patient management.
Observation:
- This report details a pediatric case involving both ceftriaxone-induced biliary pseudolithiasis and nephrolithiasis.
- The patient presented with symptoms that could be mistaken for more severe clinical issues.
- The concurrent occurrence of both biliary and renal complications was noted.
Findings:
- Ceftriaxone therapy was associated with the development of both biliary pseudolithiasis and nephrolithiasis.
- These complications, though rare, highlight a potential adverse effect profile of ceftriaxone in children.
- Resolution of symptoms was observed upon discontinuation of ceftriaxone.
Implications:
- Clinicians should consider ceftriaxone-induced biliary and renal stones in the differential diagnosis of pediatric patients on this antibiotic.
- Prompt recognition and cessation of ceftriaxone can lead to spontaneous resolution of these complications.
- Further research may elucidate the mechanisms and risk factors for these rare adverse events in pediatric populations.