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Clinical and bacteriological characteristics of IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa

Yoichi Hirakata1, Toshiyuki Yamaguchi, Michiko Nakano

  • 1Department of Laboratory Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan. hirakata@net.nagasaki-u.ac.jp

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 28, 2003
PubMed

Insights

Metallo-beta-lactamase (MBL)-producing bacteria are a growing global threat. Patients with prolonged hospitalization and certain therapies face higher risks, leading to more severe infections and increased mortality.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Metallo-beta-lactamase (MBL)-producing bacteria, particularly IMP-type, are emerging worldwide.
  • These bacteria pose a significant challenge due to limited treatment options.

Purpose of the Study:

  • To identify risk factors associated with IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa infections.
  • To compare clinical outcomes between patients with IMP-type MBL-producing pathogens and controls.

Main Methods:

  • A case-control study involving 69 inpatients with bla(IMP)-positive Pseudomonas aeruginosa and 247 controls with bla(IMP)-negative pathogens.
  • Risk factor analysis and comparison of clinical and bacteriological outcomes.

Main Results:

  • Prolonged hospitalization, chemotherapy, corticosteroid use, and urinary catheters were significant risk factors.
  • Urine was the predominant infection source. IMP-positive isolates showed higher multidrug resistance and caused more infections.
  • Infection-related mortality was significantly higher in the case group.

Conclusions:

  • Precautionary measures are crucial to prevent the spread of IMP-type MBL-producing bacteria.
  • Limited effective antibiotic options necessitate stringent infection control strategies.

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